Junichi Sadoshima Selected Research

Reactive Oxygen Species (Oxygen Radicals)

3/2024	International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
3/2021	NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.
1/2020	SIRT1-NOX4 signaling axis regulates cancer cachexia.
2/2017	Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction.
3/2016	Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase.
1/2016	Detrimental role of pericyte Nox4 in the acute phase of brain ischemia.
1/2016	Mitochondrial autophagy in cardiomyopathy.
12/2015	Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia.
1/2015	Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.
7/2014	Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion.

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Junichi Sadoshima Research Topics

Disease

43	Cardiomegaly (Heart Hypertrophy) 01/2023 - 05/2002
36	Heart Failure 10/2023 - 08/2003
31	Hypertrophy 11/2022 - 09/2002
25	Ischemia 01/2023 - 11/2002
18	Cardiomyopathies (Cardiomyopathy) 08/2023 - 02/2004
12	Fibrosis (Cirrhosis) 12/2023 - 05/2007
11	Myocardial Infarction 01/2019 - 11/2006
10	Neoplasms (Cancer) 08/2023 - 10/2010
10	Myocardial Ischemia (Ischemic Heart Diseases) 01/2023 - 05/2006
10	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 03/2011
9	Reperfusion Injury 03/2024 - 01/2011
9	Inflammation (Inflammations) 11/2023 - 11/2015
9	Heart Diseases (Heart Disease) 01/2023 - 01/2011
9	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2019 - 05/2003
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 08/2012
7	Hypertension (High Blood Pressure) 11/2022 - 07/2008
6	Obesity 12/2023 - 03/2012
6	Infarction (Infarctions) 10/2022 - 09/2010
6	Hypoxia (Hypoxemia) 05/2022 - 12/2007
5	Left Ventricular Dysfunction 11/2022 - 11/2007
5	Diabetic Cardiomyopathies 07/2021 - 01/2019
4	Insulin Resistance 11/2023 - 02/2005
4	Starvation 01/2020 - 12/2010
3	Infections 03/2021 - 09/2005
3	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2018 - 06/2014
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2014 - 03/2012
3	Body Weight (Weight, Body) 08/2010 - 07/2002
2	Non-alcoholic Fatty Liver Disease 12/2023 - 10/2022
2	Muscular Atrophy (Muscle Atrophy) 01/2019 - 07/2011
2	Proteostasis Deficiencies 10/2018 - 08/2017
2	Vascular Diseases (Vascular Disease) 02/2017 - 01/2011
2	Atherosclerosis 03/2016 - 01/2011
2	Atrial Fibrillation 12/2014 - 09/2009
2	Ventricular Remodeling 04/2013 - 11/2006
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 11/2009 - 10/2006
2	Bradycardia 02/2007 - 08/2003

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2002
14	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2024 - 11/2006
14	Sirtuin 1IBA 01/2020 - 08/2006
13	Phosphotransferases (Kinase)IBA 01/2023 - 11/2002
11	AntioxidantsIBA 12/2023 - 11/2003
10	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2023 - 08/2010
10	Beclin-1IBA 01/2022 - 03/2007
9	ThioredoxinsIBA 01/2023 - 11/2003
9	Angiotensin IIIBA 01/2017 - 09/2006
8	Mechanistic Target of Rapamycin Complex 1IBA 01/2022 - 03/2012
8	Glycogen Synthase (Synthase I)IBA 01/2021 - 09/2002
8	Protein Isoforms (Isoforms)IBA 01/2019 - 11/2009
7	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2021 - 07/2003
6	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2023 - 10/2018
6	Histone Deacetylases (Histone Deacetylase)IBA 01/2014 - 06/2008
6	Adrenergic Agents (Adrenergic Drugs)IBA 07/2011 - 07/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 03/2007
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 06/2007
5	NAD (NADH)IBA 01/2021 - 08/2006
5	beta Adrenergic ReceptorsIBA 02/2009 - 07/2003
4	Cysteine (L-Cysteine)FDA Link 01/2023 - 08/2009
4	CalcineurinIBA 01/2023 - 09/2003
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2022 - 04/2013
4	EnzymesIBA 12/2021 - 01/2014
4	Peptides (Polypeptides)IBA 04/2020 - 04/2008
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 11/2015
4	Protein Kinases (Protein Kinase)IBA 01/2019 - 06/2005
4	MicroRNAs (MicroRNA)IBA 10/2016 - 01/2011
4	Atrial Natriuretic Factor (ANF)IBA 08/2010 - 07/2002
4	Glycogen Synthase Kinase 3 betaIBA 12/2008 - 05/2002
3	NADPH Oxidase 4IBA 11/2023 - 01/2020
3	Serine (L-Serine)FDA Link 01/2022 - 12/2008
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021 - 11/2008
3	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2015
3	LipidsIBA 01/2020 - 01/2019
3	Mitochondrial Proteins (Mitochondrial Protein)IBA 10/2019 - 04/2010
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 07/2011
3	CytokinesIBA 01/2019 - 07/2002
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2018 - 05/2005
3	SaltsIBA 04/2017 - 01/2012
3	SirtuinsIBA 11/2015 - 08/2006
3	Sirolimus (Rapamycin)FDA Link 11/2014 - 08/2012
3	AMP-Activated Protein KinasesIBA 03/2011 - 03/2007
3	Caspase 3 (Caspase-3)IBA 08/2009 - 12/2007
3	Glycogen Synthase KinasesIBA 11/2007 - 05/2002
2	Glutathione (Reduced Glutathione)IBA 03/2024 - 01/2014
2	Sirtuin 3IBA 08/2023 - 11/2015
2	Sulfhydryl Compounds (Thiols)IBA 01/2023 - 01/2017
2	CollagenIBA 01/2021 - 10/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 04/2010
2	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2018
2	Dynamins (Dynamin)IBA 01/2019 - 04/2008
2	Galectin 3 (LGALS3)IBA 01/2019 - 01/2018
2	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2019 - 11/2014
2	LigandsIBA 01/2019 - 11/2013
2	SpermidineIBA 04/2017 - 12/2016
2	GTP-Binding Proteins (G-Protein)IBA 03/2014 - 08/2012
2	Glycogen Synthase Kinase 3IBA 08/2011 - 12/2008
2	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2009 - 06/2005
2	glycogen synthase kinase 3 alphaIBA 12/2008 - 11/2007
2	DNA (Deoxyribonucleic Acid)IBA 04/2008 - 11/2002
2	Insulin (Novolin)FDA Link 12/2007 - 02/2005
2	p38 Mitogen-Activated Protein KinasesIBA 12/2007 - 02/2004

Therapy/Procedure

7	Therapeutics 01/2019 - 02/2004